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Two year oral studies conducted in rats with erythromycin did not provide evidence of tumorigenicity.

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They compete with erythromycin and chloramphenicol for the same binding site but in an overlapping fashion.

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A third of those strains are multi-resistant to other drugs including erythromycin, sulphamethoxazole- trimethoprim and doxycycline.

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Macrolides, mainly erythromycin and clarithromycin, also have a class effect of qt prolongation, which can lead to torsade de pointes.

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Strong cyp3a4 inhibitors eg, itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, posaconazole, voriconazole, hiv protease inhibitors, cobicistat, nefazodone, boceprevir, telaprevir , gemfibrozil, cyclosporine, and danazol.

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