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Two year oral studies conducted in rats with erythromycin did not provide evidence of tumorigenicity.
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They compete with erythromycin and chloramphenicol for the same binding site but in an overlapping fashion.
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A third of those strains are multi-resistant to other drugs including erythromycin, sulphamethoxazole- trimethoprim and doxycycline.
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Macrolides, mainly erythromycin and clarithromycin, also have a class effect of qt prolongation, which can lead to torsade de pointes.
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Strong cyp3a4 inhibitors eg, itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, posaconazole, voriconazole, hiv protease inhibitors, cobicistat, nefazodone, boceprevir, telaprevir , gemfibrozil, cyclosporine, and danazol.
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The drugs described here include erythromycins erythrocin, ery-c, e-mycin, and other brands and medicines that are chemically related to erythromycins, such as azithromycin zithromax and clarithromycin biaxin .
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