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The fraction of the dose of bupropion excreted unchanged was only 0.
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Treatment with bupropion at both 150 and 300 mg per day was significantly more effective than placebo in this trial.
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This trial demonstrated the efficacy of bupropion for only the 450 mg dose.
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Ritonavir, lopinavir, and efavirenz concomitant treatment with these drugs can decrease bupropion and hydroxybupropion exposure.
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Data from a comparative trial of zyban, nts, the combination of bupropion plus nts, and placebo as an aid to smoking cessation suggest a higher incidence of treatment-emergent hypertension in patients treated with the combination of bupropion and nts.
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